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HYMOP aims at tackling a collective challenge put forward by a number of Flemish lead user companies: optimizing the operation and maintenance of a fleet of industrial machines. Realizing innovative modeling and data processing/analysis techniques that are able to cope with large amounts of complex data in real-time will allow these lead users, 12 of which are brought together in our Industrial Advisory Committee, to exploit the huge potential and currently underexplored opportunity enabled by ever more sensorized and connected industrial equipment.